Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

Michael E. Wechsler; Ghislaine Scelo; Désirée E. S. Larenas-Linnemann; Carlos A. Torres-Duque; Jorge Maspero; Trung N. Tran; Ruth B. Murray; Neil Martin; Andrew N. Menzies-Gow; Mark Hew; Matthew J. Peters; Peter G. Gibson; George C. Christoff; Todor A. Popov; Andréanne Côté; Celine Bergeron; Delbert Dorscheid; J. Mark FitzGerald; Kenneth R. Chapman; Louis Philippe Boulet; Mohit Bhutani; Mohsen Sadatsafavi; Libardo Jiménez-Maldonado; Mauricio Duran-Silva; Bellanid Rodriguez; Carlos Andres Celis-Preciado; Diana Jimena Cano-Rosales; Ivan Solarte; Maria Jose Fernandez-Sanchez; Patricia Parada-Tovar; Anna von Bülow; Anne Sofie Bjerrum; Charlotte S. Ulrik; Karin Dahl Assing; Linda Makowska Rasmussen; Susanne Hansen; Alan Altraja; Arnaud Bourdin; Camille Taille; Jeremy Charriot; Nicolas Roche; Andriana I. Papaioannou; Konstantinos Kostikas; Nikolaos G. Papadopoulos; Sundeep Salvi; Deirdre Long; Patrick D. Mitchell; Richard Costello; Concetta Sirena; Cristina Cardini; Enrico Heffler; Francesca Puggioni; Giorgio Walter Canonica; Giuseppe Guida; Takashi Iwanaga; Mona Al-Ahmad; Ulises García; Piotr Kuna; João A. Fonseca; Riyad Al-Lehebi; Mariko S. Koh; Chin Kook Rhee; Borja G. Cosio; Luis Perez de Llano; Diahn-Warng (Steve) Perng; Erick Wan-Chun Huang; Hao-Chien Wang; Ming-Ju Tsai; Bassam Mahboub; Laila Ibraheem Jaber Salameh; David J. Jackson; John Busby; Liam G. Heaney; Paul E. Pfeffer; Amanda Grippen Goddard; Eileen Wang; Flavia C. L. Hoyte; Nicholas M. Chapman; Rohit Katial; Victoria Carter; Lakmini Bulathsinhala; Neva Eleangovan; Con Ariti; Juntao Lyu; Celeste Porsbjerg; David B. Price

doi:10.1164/rccm.202305-0808OC

Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

Michael E. Wechsler
, Ghislaine Scelo
, Désirée E. S. Larenas-Linnemann
, Carlos A. Torres-Duque
, Jorge Maspero
, Trung N. Tran
, Ruth B. Murray
, Neil Martin
, Andrew N. Menzies-Gow
, Mark Hew
, Matthew J. Peters
, Peter G. Gibson
, George C. Christoff
, Todor A. Popov
, Andréanne Côté
, Celine Bergeron
, Delbert Dorscheid
, J. Mark FitzGerald
, Kenneth R. Chapman
, Louis Philippe Boulet

Mohit Bhutani, Mohsen Sadatsafavi, Libardo Jiménez-Maldonado, Mauricio Duran-Silva, Bellanid Rodriguez, Carlos Andres Celis-Preciado, Diana Jimena Cano-Rosales, Ivan Solarte, Maria Jose Fernandez-Sanchez, Patricia Parada-Tovar, Anna von Bülow, Anne Sofie Bjerrum, Charlotte S. Ulrik, Karin Dahl Assing, Linda Makowska Rasmussen, Susanne Hansen, Alan Altraja, Arnaud Bourdin, Camille Taille, Jeremy Charriot, Nicolas Roche, Andriana I. Papaioannou, Konstantinos Kostikas, Nikolaos G. Papadopoulos, Sundeep Salvi, Deirdre Long, Patrick D. Mitchell, Richard Costello, Concetta Sirena, Cristina Cardini, Enrico Heffler, Francesca Puggioni, Giorgio Walter Canonica, Giuseppe Guida, Takashi Iwanaga, Mona Al-Ahmad, Ulises García, Piotr Kuna, João A. Fonseca, Riyad Al-Lehebi, Mariko S. Koh, Chin Kook Rhee, Borja G. Cosio, Luis Perez de Llano, Diahn-Warng (Steve) Perng, Erick Wan-Chun Huang, Hao-Chien Wang, Ming-Ju Tsai, Bassam Mahboub, Laila Ibraheem Jaber Salameh, David J. Jackson, John Busby, Liam G. Heaney, Paul E. Pfeffer, Amanda Grippen Goddard, Eileen Wang, Flavia C. L. Hoyte, Nicholas M. Chapman, Rohit Katial, Victoria Carter, Lakmini Bulathsinhala, Neva Eleangovan, Con Ariti, Juntao Lyu, Celeste Porsbjerg, David B. Price (Correspondent Author)

Facultad De Medicina

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and
Center for Health Technology and Services Research (CINTESIS),
Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia;
Department of Respiratory Medicine, Barts Health National Hospital Service Trust, London, United Kingdom;
Pulmonary Unit, San Ignacio University Hospital, Bogota, Colombia;
Health Research Network (RISE), and
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;
Clinical Research Centre, Beaumont Hospital, Dublin, Ireland;
Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom;
Observational and Pragmatic Research Institute, Singapore;
AstraZeneca, Cambridge, United Kingdom;
Australian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South Wales, Australia;
Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Victoria, Australia;
Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark;
Cohen Family Asthma Institute and Department of Medicine,
Optimum Patient Care Global, Cambridge, United Kingdom;
Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, Mexico;
Universidad de La Sabana, Chia, Colombia;
Clinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina;
BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland;
University of Leicester, Leicester, United Kingdom;
Royal Brompton & Harefield Hospitals, London, United Kingdom;
Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia;
Department of Thoracic Medicine, Concord Hospital, Sydney, New South Wales, Australia;
Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia;
Medical University, Sofia, Bulgaria;
University Hospital Sv. Ivan Rilski, Sofia, Bulgaria;
Department of Medicine, Laval University, Quebec City, Quebec, Canada;
Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada;
Center for Heart Lung Innovation,
Department of Anesthesiology and Perioperative Medicine
University of Toronto, Toronto, Ontario, Canada;
Québec Heart and Lung Institute, Université Laval, Quebec City, Quebec, Canada;
Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada;
Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada;
Fundación Neumológica Colombiana, Atención integral y rehabilitación en asma or Comprehensive Care and Rehabilitation in Asthma (ASMAIRE) Programa, Bogotá, Colombia;
Instituto Neumológico del Oriente, Bucaramanga, Colombia;
Faculty of Medicine, Pontificia University Javeriana, Bogota, Colombia;
CINEUMO/Centro Internacional de Investigación en Neumología, Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia;
Respiratory Research Unit, Department of Respiratory Medicine and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark;
Department of Respiratory Medicine and Allergy, Aarhus University Hospital, Aarhus City, Denmark;
Department of Respiratory Medicine, Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark;
Department of Respiratory Medicine, Aalborg University Hospital, Aalborg, Denmark;
Allergy Clinic, Copenhagen University Hospital-Gentofte, Hellerup, Denmark;
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark;
Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia;
PhyMedExp, Université de Montpellier, Centre National de Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire de Montpellier, Montpellier, France;
Department of Respiratory Diseases, Bichat Hospital, Public Assistance-Hospitals of Paris North, Paris City University, Paris, France;
Department of Respiratory Medicine, Public Assistance-Hospitals of Paris North, Paris City University, Cochin Hospital and Institute (Unité Mixte de Recherche 1016), Paris, France;
2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece;
Respiratory Medicine Department, University of Ioannina, Ioannina, Greece;
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece;
Pulmocare Research and Education Foundation, Pune, India;
School of Medicine, Trinity College Dublin, Dublin, Ireland;
Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland;
Severe Asthma Network Italy, Milan, Italy;
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;
Personalized Medicine, Asthma and Allergy, Istituto di Ricovero e Cura a Carattere Scientifico Humanitas Research Hospital, Rozzano, Italy;
Department of Clinical and Biological Sciences, Severe Asthma and Rare Lung Disease Unit, San Luigi Gonzaga University Hospital, University of Turin, Turin, Italy;
Kindai University Hospital, Osakasayama, Japan;
Microbiology Department, College of Medicine, Kuwait University, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait;
Department of Allergy and Immunology, National Medical Center of Bajio, University of Guanajuato, Guanajuato, Mexico;
Division of Internal Medicine Asthma and Allergy, Medical University of Łódź, Łódź, Poland;
Departamento de Medicina da Comunidade, Informação e Decisão em Saúde (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal;
Alfaisal University, Riyadh, Saudi Arabia;
Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore;
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea;
Hospital Universitari Son Espases, Fundación Instituto de Investigación Sanitaria Islas Baleares–Ciberes, Mallorca, Spain;
Pneumology Service, Lucus Augusti University Hospital, Sergas (Galician Healthcare Service) Integrated Management Structure (EOXI) Lugo, Monforte e Cervo, Lugo, Spain;
Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;
Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan;
Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan;
School of Medicine, College of Medicine, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates;
College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;
Guy’s Severe Asthma Centre, Guy’s Hospital, King’s College London, London, United Kingdom;
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences and
Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, United Kingdom;
Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom;
Allergy Partners of Albuquerque, Albuquerque, New Mexico;
Division of Allergy and Clinical Immunology, Department of Medicine, and
Saint Joseph Hospital, National Jewish Health, Denver, Colorado;
Centre for Applied Health Economics, Griffith University, Brisbane, Australia;
Research Unit, Department of Respiratory Medicine and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark; and
Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	262-272
Journal	American Journal Of Respiratory And Critical Care Medicine
Volume	209
Issue number	3
DOIs	https://doi.org/10.1164/rccm.202305-0808OC
State	Published - 1 Feb 2024

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Vida Humana Plena (Vita)

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Full research article

Indexación Internacional (Artículo)

ISI Y SCOPUS

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Q1

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Q1

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10.1164/rccm.202305-0808OC

https://www.atsjournals.org/doi/10.1164/rccm.202305-0808OC

Cite this

Wechsler, M. E., Scelo, G., Larenas-Linnemann, D. E. S., Torres-Duque, C. A., Maspero, J., Tran, T. N., Murray, R. B., Martin, N., Menzies-Gow, A. N., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron, C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., ... Price, D. B. (2024). Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma. American Journal Of Respiratory And Critical Care Medicine, 209(3), 262-272. https://doi.org/10.1164/rccm.202305-0808OC

@article{4b54268f070c4955969e4efce3fdd707,

title = "Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma",

author = "Wechsler, \{Michael E.\} and Ghislaine Scelo and Larenas-Linnemann, \{D{\'e}sir{\'e}e E. S.\} and Torres-Duque, \{Carlos A.\} and Jorge Maspero and Tran, \{Trung N.\} and Murray, \{Ruth B.\} and Neil Martin and Menzies-Gow, \{Andrew N.\} and Mark Hew and Peters, \{Matthew J.\} and Gibson, \{Peter G.\} and Christoff, \{George C.\} and Popov, \{Todor A.\} and Andr{\'e}anne C{\^o}t{\'e} and Celine Bergeron and Delbert Dorscheid and FitzGerald, \{J. Mark\} and Chapman, \{Kenneth R.\} and Boulet, \{Louis Philippe\} and Mohit Bhutani and Mohsen Sadatsafavi and Libardo Jim{\'e}nez-Maldonado and Mauricio Duran-Silva and Bellanid Rodriguez and Celis-Preciado, \{Carlos Andres\} and Cano-Rosales, \{Diana Jimena\} and Ivan Solarte and Fernandez-Sanchez, \{Maria Jose\} and Patricia Parada-Tovar and \{von B{\"u}low\}, Anna and Bjerrum, \{Anne Sofie\} and Ulrik, \{Charlotte S.\} and Assing, \{Karin Dahl\} and Rasmussen, \{Linda Makowska\} and Susanne Hansen and Alan Altraja and Arnaud Bourdin and Camille Taille and Jeremy Charriot and Nicolas Roche and Papaioannou, \{Andriana I.\} and Konstantinos Kostikas and Papadopoulos, \{Nikolaos G.\} and Sundeep Salvi and Deirdre Long and Mitchell, \{Patrick D.\} and Richard Costello and Concetta Sirena and Cristina Cardini and Enrico Heffler and Francesca Puggioni and Canonica, \{Giorgio Walter\} and Giuseppe Guida and Takashi Iwanaga and Mona Al-Ahmad and Ulises Garc{\'i}a and Piotr Kuna and Fonseca, \{Jo{\~a}o A.\} and Riyad Al-Lehebi and Koh, \{Mariko S.\} and Rhee, \{Chin Kook\} and Cosio, \{Borja G.\} and \{Perez de Llano\}, Luis and Perng, \{Diahn-Warng (Steve)\} and Huang, \{Erick Wan-Chun\} and Hao-Chien Wang and Ming-Ju Tsai and Bassam Mahboub and Salameh, \{Laila Ibraheem Jaber\} and Jackson, \{David J.\} and John Busby and Heaney, \{Liam G.\} and Pfeffer, \{Paul E.\} and Goddard, \{Amanda Grippen\} and Eileen Wang and Hoyte, \{Flavia C. L.\} and Chapman, \{Nicholas M.\} and Rohit Katial and Victoria Carter and Lakmini Bulathsinhala and Neva Eleangovan and Con Ariti and Juntao Lyu and Celeste Porsbjerg and Price, \{David B.\}",

year = "2024",

month = feb,

day = "1",

doi = "10.1164/rccm.202305-0808OC",

language = "Ingl{\'e}s",

volume = "209",

pages = "262--272",

journal = "American Journal Of Respiratory And Critical Care Medicine",

issn = "1073-449X",

publisher = "Oxford University Press",

number = "3",

}

Wechsler, ME, Scelo, G, Larenas-Linnemann, DES, Torres-Duque, CA, Maspero, J, Tran, TN, Murray, RB, Martin, N, Menzies-Gow, AN, Hew, M, Peters, MJ, Gibson, PG, Christoff, GC, Popov, TA, Côté, A, Bergeron, C, Dorscheid, D, FitzGerald, JM, Chapman, KR, Boulet, LP, Bhutani, M, Sadatsafavi, M, Jiménez-Maldonado, L, Duran-Silva, M, Rodriguez, B, Celis-Preciado, CA, Cano-Rosales, DJ, Solarte, I, Fernandez-Sanchez, MJ, Parada-Tovar, P, von Bülow, A, Bjerrum, AS, Ulrik, CS, Assing, KD, Rasmussen, LM, Hansen, S, Altraja, A, Bourdin, A, Taille, C, Charriot, J, Roche, N, Papaioannou, AI, Kostikas, K, Papadopoulos, NG, Salvi, S, Long, D, Mitchell, PD, Costello, R, Sirena, C, Cardini, C, Heffler, E, Puggioni, F, Canonica, GW, Guida, G, Iwanaga, T, Al-Ahmad, M, García, U, Kuna, P, Fonseca, JA, Al-Lehebi, R, Koh, MS, Rhee, CK, Cosio, BG, Perez de Llano, L, Perng, D-W, Huang, EW-C, Wang, H-C, Tsai, M-J, Mahboub, B, Salameh, LIJ, Jackson, DJ, Busby, J, Heaney, LG, Pfeffer, PE, Goddard, AG, Wang, E, Hoyte, FCL, Chapman, NM, Katial, R, Carter, V, Bulathsinhala, L, Eleangovan, N, Ariti, C, Lyu, J, Porsbjerg, C & Price, DB 2024, 'Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma', American Journal Of Respiratory And Critical Care Medicine, vol. 209, no. 3, pp. 262-272. https://doi.org/10.1164/rccm.202305-0808OC

TY - JOUR

T1 - Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

AU - Wechsler, Michael E.

AU - Scelo, Ghislaine

AU - Larenas-Linnemann, Désirée E. S.

AU - Torres-Duque, Carlos A.

AU - Maspero, Jorge

AU - Tran, Trung N.

AU - Murray, Ruth B.

AU - Martin, Neil

AU - Menzies-Gow, Andrew N.

AU - Hew, Mark

AU - Peters, Matthew J.

AU - Gibson, Peter G.

AU - Christoff, George C.

AU - Popov, Todor A.

AU - Côté, Andréanne

AU - Bergeron, Celine

AU - Dorscheid, Delbert

AU - FitzGerald, J. Mark

AU - Chapman, Kenneth R.

AU - Boulet, Louis Philippe

AU - Bhutani, Mohit

AU - Sadatsafavi, Mohsen

AU - Jiménez-Maldonado, Libardo

AU - Duran-Silva, Mauricio

AU - Rodriguez, Bellanid

AU - Celis-Preciado, Carlos Andres

AU - Cano-Rosales, Diana Jimena

AU - Solarte, Ivan

AU - Fernandez-Sanchez, Maria Jose

AU - Parada-Tovar, Patricia

AU - von Bülow, Anna

AU - Bjerrum, Anne Sofie

AU - Ulrik, Charlotte S.

AU - Assing, Karin Dahl

AU - Rasmussen, Linda Makowska

AU - Hansen, Susanne

AU - Altraja, Alan

AU - Bourdin, Arnaud

AU - Taille, Camille

AU - Charriot, Jeremy

AU - Roche, Nicolas

AU - Papaioannou, Andriana I.

AU - Kostikas, Konstantinos

AU - Papadopoulos, Nikolaos G.

AU - Salvi, Sundeep

AU - Long, Deirdre

AU - Mitchell, Patrick D.

AU - Costello, Richard

AU - Sirena, Concetta

AU - Cardini, Cristina

AU - Heffler, Enrico

AU - Puggioni, Francesca

AU - Canonica, Giorgio Walter

AU - Guida, Giuseppe

AU - Iwanaga, Takashi

AU - Al-Ahmad, Mona

AU - García, Ulises

AU - Kuna, Piotr

AU - Fonseca, João A.

AU - Al-Lehebi, Riyad

AU - Koh, Mariko S.

AU - Rhee, Chin Kook

AU - Cosio, Borja G.

AU - Perez de Llano, Luis

AU - Perng, Diahn-Warng (Steve)

AU - Huang, Erick Wan-Chun

AU - Wang, Hao-Chien

AU - Tsai, Ming-Ju

AU - Mahboub, Bassam

AU - Salameh, Laila Ibraheem Jaber

AU - Jackson, David J.

AU - Busby, John

AU - Heaney, Liam G.

AU - Pfeffer, Paul E.

AU - Goddard, Amanda Grippen

AU - Wang, Eileen

AU - Hoyte, Flavia C. L.

AU - Chapman, Nicholas M.

AU - Katial, Rohit

AU - Carter, Victoria

AU - Bulathsinhala, Lakmini

AU - Eleangovan, Neva

AU - Ariti, Con

AU - Lyu, Juntao

AU - Porsbjerg, Celeste

AU - Price, David B.

PY - 2024/2/1

Y1 - 2024/2/1

U2 - 10.1164/rccm.202305-0808OC

DO - 10.1164/rccm.202305-0808OC

M3 - Artículo

SN - 1073-449X

VL - 209

SP - 262

EP - 272

JO - American Journal Of Respiratory And Critical Care Medicine

JF - American Journal Of Respiratory And Critical Care Medicine

IS - 3

ER -

Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

Strategic Focuses

Article Classification

Indexación Internacional (Artículo)

Scopus-Q Quartil

ISI- Q Quartil

Categoría Publindex

Access to Document

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Cite this