Comparison of the Predictive Capacity of Oxygenation  Parameters, Oxygenation Indices, and CURB-65 to Mortality,  Mechanical Ventilation, and Vasopressor Support in  Community-Acquired Pneumonia at Different Altitudes

Alirio Rodrigo Bastidas Goyes; Eduardo Andres Tuta Quintero; Angelica Vanessa Mora Barrero; Luis Felipe Reyes; Laura Elizabeth Bello Sarmiento; Alejandra Paola Nonzoque Moreno; Laura Daniela Saza Salas; Natalia Trujillo Angel; Jeniffer Camila Arias Arismendy; Paola Mejia Martínez; Daniel Osorio Mañaca; Paula Oriana Narvaez Ramirez; Laura Sofia Perdomo Rodriguez; Luis Miguel Vargas Arcila; Maria Alejandra Perez Hernandez; Jesús Fernando Rubiano; Paula Catalina Pinillos; Juan Manuel Naranjo Piñeros; Angela Maria Martinez Covaleda

doi:10.1155/carj/9378618

Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes

Alirio Rodrigo Bastidas Goyes (Correspondent Author)
, Eduardo Andres Tuta Quintero (masterstudent)
, Angelica Vanessa Mora Barrero (masterstudent)
, Luis Felipe Reyes (Fourth Autor)
, Laura Elizabeth Bello Sarmiento (undergradstudent)
, Alejandra Paola Nonzoque Moreno (undergradstudent)
, Laura Daniela Saza Salas (masterstudent)
, Natalia Trujillo Angel (undergradstudent)
, Jeniffer Camila Arias Arismendy (undergradstudent)
, Paola Mejia Martínez (undergradstudent)
, Daniel Osorio Mañaca (masterstudent)
, Paula Oriana Narvaez Ramirez (undergradstudent)
, Laura Sofia Perdomo Rodriguez (undergradstudent)
, Luis Miguel Vargas Arcila (undergradstudent)
, Maria Alejandra Perez Hernandez (masterstudent)
, Jesús Fernando Rubiano (undergradstudent)
, Paula Catalina Pinillos (undergradstudent)
, Juan Manuel Naranjo Piñeros (undergradstudent)
, Angela Maria Martinez Covaleda (undergradstudent)

Universidad de la Sabana

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Populations residing at high altitudes display distinct physiological adaptations that are essential for understanding respiratory diseases. However, there is limited research on how these adaptations affect the assessment and prognosis of community-acquired pneumonia (CAP). Methods: A prognostic validation nested within a retrospective cohort was conducted on subjects with pneumonia admitted to two high-complexity institutions in Colombia at different altitudes above sea level. The receiver operating characteristic (ROC) curves were calculated for SaO ₂, PaO ₂, SpO ₂, A-a O ₂ gradient, a-A index, PaO ₂/FiO ₂, SpO ₂/FiO ₂, and the CURB-65 score to predict 30-day mortality, requirement for invasive mechanical ventilation (IMV), and need for vasopressor support. Results: 3467 were selected for analysis, with 73.7% (2557/3467) residing at high altitudes and 26.2% (910/3467) at low altitudes. The CURB-65 score ≥ 2 showed a performance in predicting mortality of 0.707 (95% CI: 0.653–0.761; p < 0.001) at low altitudes and 0.737 (95% CI: 0.709–0.765; p < 0.001) at high altitudes. The PaO ₂/FiO ₂ ≤ 300 showed a performance in predicting the need for IMV and vasopressor support of 0.734 (95% CI: 0.685–0.783; p < 0.001) and 0.724 (0.674–0.775; p < 0.001) at high altitudes, respectively. The SpO ₂/FiO ₂ ≤ 350 showed a performance in predicting the need for IMV of 0.679 (0.507–0.85; p < 0.001) at low altitudes. The A-a O ₂ gradient ≥ 10 showed a performance in predicting the need for vasopressor support of 0.686 (95% CI: 0.537–0.835; p = 0.06) at low altitudes. Conclusion: In patients with CAP at altitudes above 2500 m above sea level, PaO ₂/FiO ₂, SpO ₂/FiO ₂, and the A-a O ₂ gradient show a greater predictive capacity for 30-day mortality, need for IMV, and vasopressor requirements. The CURB-65 score showed a good predictive performance.

Original language	English
Article number	9378618
Pages (from-to)	1-9
Journal	Canadian Respiratory Journal
Volume	2025
Issue number	1
DOIs	https://doi.org/10.1155/carj/9378618
State	Published - 11 Mar 2025

Strategic Focuses

Vida Humana Plena (Vita)

Article Classification

Full research article

Indexación Internacional (Artículo)

ISI Y SCOPUS

Scopus-Q Quartil

Q2

ISI- Q Quartil

Q3

Categoría Publindex

A2

Access to Document

10.1155/carj/9378618

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Bastidas Goyes, A. R., Tuta Quintero, E. A., Mora Barrero, A. V., Reyes, L. F., Bello Sarmiento, L. E., Nonzoque Moreno, A. P., Saza Salas, L. D., Trujillo Angel, N., Arias Arismendy, J. C., Mejia Martínez , P., Osorio Mañaca, D., Narvaez Ramirez, P. O., Perdomo Rodriguez, L. S., Vargas Arcila, L. M., Perez Hernandez, M. A., Rubiano, J. F., Pinillos, P. C., Naranjo Piñeros, J. M., & Martinez Covaleda, A. M. (2025). Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes. Canadian Respiratory Journal, 2025(1), 1-9. Article 9378618. https://doi.org/10.1155/carj/9378618

Bastidas Goyes, Alirio Rodrigo ; Tuta Quintero, Eduardo Andres ; Mora Barrero, Angelica Vanessa et al. / Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes. In: Canadian Respiratory Journal. 2025 ; Vol. 2025, No. 1. pp. 1-9.

@article{35b61c2136b2499699c55c180d58be18,

title = "Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes",

abstract = "Background: Populations residing at high altitudes display distinct physiological adaptations that are essential for understanding respiratory diseases. However, there is limited research on how these adaptations affect the assessment and prognosis of community-acquired pneumonia (CAP). Methods: A prognostic validation nested within a retrospective cohort was conducted on subjects with pneumonia admitted to two high-complexity institutions in Colombia at different altitudes above sea level. The receiver operating characteristic (ROC) curves were calculated for SaO 2, PaO 2, SpO 2, A-a O 2 gradient, a-A index, PaO 2/FiO 2, SpO 2/FiO 2, and the CURB-65 score to predict 30-day mortality, requirement for invasive mechanical ventilation (IMV), and need for vasopressor support. Results: 3467 were selected for analysis, with 73.7\% (2557/3467) residing at high altitudes and 26.2\% (910/3467) at low altitudes. The CURB-65 score ≥ 2 showed a performance in predicting mortality of 0.707 (95\% CI: 0.653–0.761; p < 0.001) at low altitudes and 0.737 (95\% CI: 0.709–0.765; p < 0.001) at high altitudes. The PaO 2/FiO 2 ≤ 300 showed a performance in predicting the need for IMV and vasopressor support of 0.734 (95\% CI: 0.685–0.783; p < 0.001) and 0.724 (0.674–0.775; p < 0.001) at high altitudes, respectively. The SpO 2/FiO 2 ≤ 350 showed a performance in predicting the need for IMV of 0.679 (0.507–0.85; p < 0.001) at low altitudes. The A-a O 2 gradient ≥ 10 showed a performance in predicting the need for vasopressor support of 0.686 (95\% CI: 0.537–0.835; p = 0.06) at low altitudes. Conclusion: In patients with CAP at altitudes above 2500 m above sea level, PaO 2/FiO 2, SpO 2/FiO 2, and the A-a O 2 gradient show a greater predictive capacity for 30-day mortality, need for IMV, and vasopressor requirements. The CURB-65 score showed a good predictive performance.",

author = "\{Bastidas Goyes\}, \{Alirio Rodrigo\} and \{Tuta Quintero\}, \{Eduardo Andres\} and \{Mora Barrero\}, \{Angelica Vanessa\} and Reyes, \{Luis Felipe\} and \{Bello Sarmiento\}, \{Laura Elizabeth\} and \{Nonzoque Moreno\}, \{Alejandra Paola\} and \{Saza Salas\}, \{Laura Daniela\} and \{Trujillo Angel\}, Natalia and \{Arias Arismendy\}, \{Jeniffer Camila\} and \{Mejia Mart{\'i}nez\}, Paola and \{Osorio Ma{\~n}aca\}, Daniel and \{Narvaez Ramirez\}, \{Paula Oriana\} and \{Perdomo Rodriguez\}, \{Laura Sofia\} and \{Vargas Arcila\}, \{Luis Miguel\} and \{Perez Hernandez\}, \{Maria Alejandra\} and Rubiano, \{Jes{\'u}s Fernando\} and Pinillos, \{Paula Catalina\} and \{Naranjo Pi{\~n}eros\}, \{Juan Manuel\} and \{Martinez Covaleda\}, \{Angela Maria\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Eduardo Tuta-Quintero et al. Canadian Respiratory Journal published by John Wiley \& Sons Ltd.",

year = "2025",

month = mar,

day = "11",

doi = "10.1155/carj/9378618",

language = "Ingl{\'e}s",

volume = "2025",

pages = "1--9",

journal = "Canadian Respiratory Journal",

issn = "1198-2241",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

Bastidas Goyes, AR, Tuta Quintero, EA, Mora Barrero, AV, Reyes, LF, Bello Sarmiento, LE, Nonzoque Moreno, AP, Saza Salas, LD, Trujillo Angel, N, Arias Arismendy, JC, Mejia Martínez , P, Osorio Mañaca, D, Narvaez Ramirez, PO, Perdomo Rodriguez, LS, Vargas Arcila, LM, Perez Hernandez, MA, Rubiano, JF, Pinillos, PC, Naranjo Piñeros, JM & Martinez Covaleda, AM 2025, 'Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes', Canadian Respiratory Journal, vol. 2025, no. 1, 9378618, pp. 1-9. https://doi.org/10.1155/carj/9378618

Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes. / Bastidas Goyes, Alirio Rodrigo (Correspondent Author); Tuta Quintero, Eduardo Andres (masterstudent); Mora Barrero, Angelica Vanessa (masterstudent) et al.
In: Canadian Respiratory Journal, Vol. 2025, No. 1, 9378618, 11.03.2025, p. 1-9.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes

AU - Bastidas Goyes, Alirio Rodrigo

A2 - Tuta Quintero, Eduardo Andres

A2 - Mora Barrero, Angelica Vanessa

A2 - Reyes, Luis Felipe

A2 - Bello Sarmiento, Laura Elizabeth

A2 - Nonzoque Moreno, Alejandra Paola

A2 - Saza Salas, Laura Daniela

A2 - Trujillo Angel, Natalia

A2 - Arias Arismendy, Jeniffer Camila

A2 - Mejia Martínez , Paola

A2 - Osorio Mañaca, Daniel

A2 - Narvaez Ramirez, Paula Oriana

A2 - Perdomo Rodriguez, Laura Sofia

A2 - Vargas Arcila, Luis Miguel

A2 - Perez Hernandez, Maria Alejandra

A2 - Rubiano, Jesús Fernando

A2 - Pinillos, Paula Catalina

A2 - Naranjo Piñeros, Juan Manuel

A2 - Martinez Covaleda, Angela Maria

PY - 2025/3/11

Y1 - 2025/3/11

N2 - Background: Populations residing at high altitudes display distinct physiological adaptations that are essential for understanding respiratory diseases. However, there is limited research on how these adaptations affect the assessment and prognosis of community-acquired pneumonia (CAP). Methods: A prognostic validation nested within a retrospective cohort was conducted on subjects with pneumonia admitted to two high-complexity institutions in Colombia at different altitudes above sea level. The receiver operating characteristic (ROC) curves were calculated for SaO 2, PaO 2, SpO 2, A-a O 2 gradient, a-A index, PaO 2/FiO 2, SpO 2/FiO 2, and the CURB-65 score to predict 30-day mortality, requirement for invasive mechanical ventilation (IMV), and need for vasopressor support. Results: 3467 were selected for analysis, with 73.7% (2557/3467) residing at high altitudes and 26.2% (910/3467) at low altitudes. The CURB-65 score ≥ 2 showed a performance in predicting mortality of 0.707 (95% CI: 0.653–0.761; p < 0.001) at low altitudes and 0.737 (95% CI: 0.709–0.765; p < 0.001) at high altitudes. The PaO 2/FiO 2 ≤ 300 showed a performance in predicting the need for IMV and vasopressor support of 0.734 (95% CI: 0.685–0.783; p < 0.001) and 0.724 (0.674–0.775; p < 0.001) at high altitudes, respectively. The SpO 2/FiO 2 ≤ 350 showed a performance in predicting the need for IMV of 0.679 (0.507–0.85; p < 0.001) at low altitudes. The A-a O 2 gradient ≥ 10 showed a performance in predicting the need for vasopressor support of 0.686 (95% CI: 0.537–0.835; p = 0.06) at low altitudes. Conclusion: In patients with CAP at altitudes above 2500 m above sea level, PaO 2/FiO 2, SpO 2/FiO 2, and the A-a O 2 gradient show a greater predictive capacity for 30-day mortality, need for IMV, and vasopressor requirements. The CURB-65 score showed a good predictive performance.

AB - Background: Populations residing at high altitudes display distinct physiological adaptations that are essential for understanding respiratory diseases. However, there is limited research on how these adaptations affect the assessment and prognosis of community-acquired pneumonia (CAP). Methods: A prognostic validation nested within a retrospective cohort was conducted on subjects with pneumonia admitted to two high-complexity institutions in Colombia at different altitudes above sea level. The receiver operating characteristic (ROC) curves were calculated for SaO 2, PaO 2, SpO 2, A-a O 2 gradient, a-A index, PaO 2/FiO 2, SpO 2/FiO 2, and the CURB-65 score to predict 30-day mortality, requirement for invasive mechanical ventilation (IMV), and need for vasopressor support. Results: 3467 were selected for analysis, with 73.7% (2557/3467) residing at high altitudes and 26.2% (910/3467) at low altitudes. The CURB-65 score ≥ 2 showed a performance in predicting mortality of 0.707 (95% CI: 0.653–0.761; p < 0.001) at low altitudes and 0.737 (95% CI: 0.709–0.765; p < 0.001) at high altitudes. The PaO 2/FiO 2 ≤ 300 showed a performance in predicting the need for IMV and vasopressor support of 0.734 (95% CI: 0.685–0.783; p < 0.001) and 0.724 (0.674–0.775; p < 0.001) at high altitudes, respectively. The SpO 2/FiO 2 ≤ 350 showed a performance in predicting the need for IMV of 0.679 (0.507–0.85; p < 0.001) at low altitudes. The A-a O 2 gradient ≥ 10 showed a performance in predicting the need for vasopressor support of 0.686 (95% CI: 0.537–0.835; p = 0.06) at low altitudes. Conclusion: In patients with CAP at altitudes above 2500 m above sea level, PaO 2/FiO 2, SpO 2/FiO 2, and the A-a O 2 gradient show a greater predictive capacity for 30-day mortality, need for IMV, and vasopressor requirements. The CURB-65 score showed a good predictive performance.

UR - https://onlinelibrary.wiley.com/doi/10.1155/carj/9378618

UR - https://www.scopus.com/pages/publications/105002142969

U2 - 10.1155/carj/9378618

DO - 10.1155/carj/9378618

M3 - Artículo

SN - 1198-2241

VL - 2025

SP - 1

EP - 9

JO - Canadian Respiratory Journal

JF - Canadian Respiratory Journal

IS - 1

M1 - 9378618

ER -

Bastidas Goyes AR, Tuta Quintero EA, Mora Barrero AV, Reyes LF, Bello Sarmiento LE, Nonzoque Moreno AP et al. Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes. Canadian Respiratory Journal. 2025 Mar 11;2025(1):1-9. 9378618. doi: 10.1155/carj/9378618