Factors of poor prognosis in newborns with a prenatal diagnosis of gastroschisis in Bogota, Colombia

Objectives: To identify factors associated with poor prognoses in newborns with a prenatal diagnosis of gastroschisis in eight hospitals in Bogota, Colombia, from 2011 to 2022. Methods: A multi-center retrospective case-control study was conducted on newborns with gastroschisis in eight hospitals in Bogota, Colombia. Poor prognosis was defined as the presence of sepsis, intestinal complications, or death. Results: The study included 101 patients. Preterm newborns under 32 weeks had a poor neonatal prognosis (OR 6.78 95% CI 0.75-319). Oligohydramnios (OR 4.95 95% CI 1.15-21.32) and staged closure with silo (OR 3.48; 95% CI 1.10-10.96) were risk factors for neonatal death, and intra-Abdominal bowel dilation of 20-25mm was a factor for the development of intestinal complications (OR 3.22 95% CI 1.26-8.23). Conclusions: Intra-Abdominal bowel dilation between 20 and 25mm was associated with intestinal complications, while oligohydramnios was associated with the risk of perinatal death, requiring increased antenatal surveillance of fetal wellbeing. Management with primary reduction when technically feasible is recommended in these infants, considering that the use of silos was associated with higher mortality.