High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

Daniel Uricoechea Patiño; Andrew Collins; Oscar Julián Romero García; Gustavo Santos Vecino; José Vicente Rodríguez Cuenca; Jaime E. Bernal; Escilda Benavides Benítez; Saray Vergara Muñoz; Ignacio Briceño Balcázar

doi:10.3390/genes14101853

High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

Daniel Uricoechea Patiño (Estudiante de doctorado), Andrew Collins, Oscar Julián Romero García, Gustavo Santos Vecino, José Vicente Rodríguez Cuenca, Jaime E. Bernal, Escilda Benavides Benítez, Saray Vergara Muñoz, Ignacio Briceño Balcázar (Autor Corresponsal)

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Resumen

The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.

Idioma original	Inglés
Número de artículo	1853
Publicación	Genes
Volumen	14
N.º	10
DOI	https://doi.org/10.3390/genes14101853
Estado	Publicada - oct. 2023

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title = "High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia",

abstract = "The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.",

author = "\{Uricoechea Pati{\~n}o\}, Daniel and Andrew Collins and Garc{\'i}a, \{Oscar Juli{\'a}n Romero\} and \{Santos Vecino\}, Gustavo and Cuenca, \{Jos{\'e} Vicente Rodr{\'i}guez\} and Bernal, \{Jaime E.\} and \{Benavides Ben{\'i}tez\}, Escilda and \{Vergara Mu{\~n}oz\}, Saray and \{Brice{\~n}o Balc{\'a}zar\}, Ignacio",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = oct,

doi = "10.3390/genes14101853",

language = "Ingl{\'e}s",

volume = "14",

journal = "Genes",

issn = "2073-4425",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

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TY - JOUR

T1 - High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

AU - Collins, Andrew

AU - García, Oscar Julián Romero

AU - Santos Vecino, Gustavo

AU - Cuenca, José Vicente Rodríguez

AU - Bernal, Jaime E.

AU - Benavides Benítez, Escilda

AU - Vergara Muñoz, Saray

AU - Briceño Balcázar, Ignacio

A2 - Uricoechea Patiño, Daniel

PY - 2023/10

Y1 - 2023/10

N2 - The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.

AB - The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.

UR - https://www.scopus.com/pages/publications/85175379340

U2 - 10.3390/genes14101853

DO - 10.3390/genes14101853

M3 - Artículo

AN - SCOPUS:85175379340

SN - 2073-4425

VL - 14

JO - Genes

JF - Genes

IS - 10

M1 - 1853

ER -

High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

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