Resumen
Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression. Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18–88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated measures of reward responsiveness, OCD, and depression. Network analyses evaluated interrelations among reward responsiveness domains and their links to OCD and depression. Results: Hobbies and social interactions were the most central domains in the reward responsiveness network. Higher OCD severity was uniquely associated with lower responsiveness to social interactions, while higher depression severity was uniquely linked to reduced responsiveness in hobbies and goal-directed behaviors. Conclusions: Reward responsiveness is relevant to both OCD and depression. Interventions that enhance engagement in central domains, such as hobbies and social interactions, may improve outcomes. Future research should explore reward responsiveness in other mental disorders to inform transdiagnostic intervention strategies.
| Idioma original | Inglés |
|---|---|
| Número de artículo | 119886 |
| Publicación | Journal of Affective Disorders |
| Volumen | 391 |
| DOI | |
| Estado | Publicada - 15 dic. 2025 |
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En: Journal of Affective Disorders, Vol. 391, 119886, 15.12.2025.
Producción científica: Contribución a una revista › Artículo › revisión exhaustiva
TY - JOUR
T1 - Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression
AU - Wagner, Kevin M.
AU - Cervin, Matti
AU - Cheng, Jessica S.C.
AU - Cruz, Vanessa Zavala
AU - Berrones, Dayan
AU - Muñoz, Josselyn S.
AU - Frederick, Renee M.
AU - Anderberg, Jacey L.
AU - Núñez Bracho, Belinda E.
AU - Adorno, Victor R.
AU - Fontenelle, Leonardo F.
AU - Wiese, Andrew D.
AU - Agostini, Victoria
AU - Aguilar, William W.
AU - Aguirre, Cinthia
AU - Alvarado-Quiroz, Valentina
AU - Ancalade, Na Eshia
AU - Anciburo, Maria E.
AU - Antich, Amira Y.
AU - Aponte, Diego
AU - Arellano Espinosa, Alejandro A.
AU - Arnold, Paul D.
AU - Carmelo, Brygith Asenjo
AU - Atkinson, Elizabeth G.
AU - Avanesyan, Tatevik
AU - Avery, Juliana E.
AU - Ayala, Jose N.
AU - Aziz, Hala
AU - Barbieri Aguirre, Tania L.
AU - Barrera, Cynthia N.
AU - Barrero Contreras, Julian A.
AU - Barry, Kelly
AU - Belanger, Amanda N.
AU - Benitez, Laura M.
AU - Best, John R.
AU - Bigdeli, Tim B.
AU - Bommiasamy, Hemamalini
AU - Borda, Tania
AU - Boyajian, Laura
AU - Muñoz, Diego Briceño
AU - Browning, Lauren
AU - Burton, Christie L.
AU - Busto, Carolina
AU - Buxbaum, Joseph D.
AU - Calderón Rivera, Ricardo E.
AU - Callahan, Jennifer L.
AU - Camacho Gomez, Carlos A.
AU - Campos Ponce, Laura A.
AU - Canchari, Ernesto G.
AU - Torres, Roxana Carrasco
AU - Chang, Alexandria
AU - Chazelle, Evelyn
AU - Chire, Jessica M.
AU - Muñoz, Macarena Churruca
AU - Cicero, David C.
AU - Cifuentes-Espinoza, Amanda P.
AU - Quiroz, Pamela Claisse
AU - Colombo, Gianna M.
AU - Comer, Jonathan S.
AU - Condori-Apaza, Luz
AU - Cortina, Jennifer
AU - Crosbie, Jennifer
AU - Cruz, Victor O.
AU - Cruz, Isabella A.
AU - Cunning, Allison
AU - Dager Perez, Guillermo J.
AU - Dailey, Megan M.
AU - Dang, Brian D.
AU - Davalos Checco, Kelly L.
AU - Dawson, Alyssa
AU - del Río, Daniela
AU - Dev, Amelia
AU - Diaz, Sara
AU - Estrada, Florencia S.
AU - Figueroa, Edith G.
AU - Flecha, Letizia M.
AU - Flores-Garcia, Álvaro M.
AU - Franklin, Martin E.
AU - Fujita, Ricardo
AU - Furr, Jami M.
AU - Gaeta, Alessa
AU - Gamarra, Olivia M.
AU - Garay-Contreras, Camila
AU - García-Bravo, Nataly
AU - García-Jaimes, Cynthia
AU - Garrison, Sheldon R.
AU - Gil-Hernández, Dariana
AU - Giusti-Rodriguez, Paola
AU - Gonzalez, Amin
AU - González, Ramon A.
AU - Gonzalez-Barrios, Polaris
AU - Goodman, Wayne K.
AU - Gorosito, Javier D.
AU - Grice, Dorothy E.
AU - Guintivano, Jerry
AU - Guttfreund, Daniel G.
AU - Halvorsen, Matthew W.
AU - Haslop Miles, Jorge A.R.
AU - Hernández Núñez, Estefanía V.
AU - Hettema, John M.
AU - Hovey, Joseph D.
AU - Ccarhuas, Bryan Huerta
AU - Irreño-Sotomonte, Jonathan
AU - Jagannathan, Nisha
AU - Jensen, Matias
AU - Jimenez Reynolds, Alexandra Z.
AU - Jiwani, Rozmin B.
AU - Johnson, Jessica S.
AU - Joutteaux, Sonia
AU - Lujambio, Joali Alexandra Juárez
AU - Kehrer, Sabrina
AU - Kennedy, James L.
AU - Lanzagorta, Nuria
AU - Lázaro-Muñoz, Gabriel
AU - Longhurst, Melanie
AU - Lozada Martinez, David A.
AU - Luna, Elba S.
AU - MacLellan, Anna
AU - Quispe, Dora Mamani
AU - Marques, Andrea H.
AU - Marquez, Mainor R.
AU - Martinez, Molly
AU - Martínez, Galo N.
AU - Martinez Mallen, Mayra C.
AU - Martinez-Gonzalez, Karen G.
AU - de Los Angeles Matos, Maria
AU - Mattheisen, Manuel
AU - Mccarty, Ryan J.
AU - McGuire, Joseph F.
AU - McKay, Dean
AU - McOmber, Ciara
AU - Minaya, Charlene
AU - Miño, Tomás
AU - Mithani, Sara M.
AU - Morales-Rivero, Alonso
AU - Moya, Pablo R.
AU - Moyano, María B.
AU - Mukunda, Pavithra
AU - Muñoz, Maria J.
AU - Nicolini, Humberto
AU - Núñez Bracho, Ambar A.
AU - Obando, Diana P.
AU - Ochoa, Monica E.
AU - Ochoa-Panaifo, Marcos E.
AU - O'Higgins, Marcelo
AU - Olavarria Castaman, Luis A.
AU - Balmaceda, Trinidad Olivos
AU - Olmedo Tobar, María J.
AU - Onyeka, Ogechi C.
AU - Ortega, Iliana
AU - Paredes-Linares, Vanessa S.
AU - Pato, Michele T.
AU - Miño, Mariel Paz y.
AU - de Leon, Edilberto Peña
AU - Perales Orellana, José L.
AU - Peralta Sossa, Noelia S.
AU - Pereira, Stacey
AU - Pereira Morales, Natalia A.
AU - Duarte, Tania Pérez
AU - Phan, Angel
AU - Placencia, Maritza
AU - Ponce, Lorena
AU - Poovey, Kendall
AU - Qiao, Thomas
AU - Quiroz-Padilla, Maria F.
AU - Correa, María F.Quispe
AU - Ramirez Heros, Alessandra S.
AU - Ramos, Renato T.
AU - Ramos, Iaroslava C.
AU - Ramsey, Kesley A.
AU - Rancourt, Diana
AU - Gomez, Sebastian Rebatta
AU - Reyes Espinosa, Rocío C.
AU - Richter, Peggy
AU - Rodriguez, Carolyn I.
AU - Barajas, Servando Rodriguez
AU - Romero, Maritza J.
AU - Ruggero, Camilo J.
AU - Ruiz-Chow, Angel
AU - Sagarnaga, Melisa N.
AU - Salazar Montoya, Gianella N.
AU - Salhadar, Nadeen
AU - Schachar, Russell J.
AU - Segovia, Lucia M.
AU - Seligman, Laura D.
AU - Siegel, Isaac J.
AU - Spencer, Samuel D.
AU - Staples, Cody
AU - Stewart, S. Evelyn
AU - Storch, Eric A.
AU - Tapia-Cuevas, Vissente
AU - Thompson, Peter
AU - Timpano, Kiara R.
AU - Tonarelli, Silvina
AU - la Garza, Beatriz Treviño de
AU - Trujillo, Angela
AU - Villar, Constanza Uribe
AU - Valdés, Carolina
AU - Vallejo-Silva, Alexie
AU - Vargas Mamani, Katerin N.
AU - Vargas-Medrano, Javier
AU - Vásquez-Suyo, María I.
AU - Ver Mellstrieng, Anne
AU - Vergara, Maria V.
AU - Vidal-Martinez, Guadalupe
AU - Vilchez Huaman, Mariluz V.
AU - Vollaro, Caroline
AU - Wilkerson, Sara
AU - Zai, Gwyneth
AU - Zappa, Luz M.
AU - Zepeda-Burgos, Raquel M.
AU - Zoghbi, Anthony W.
AU - Alves, Gustavo S.
AU - Alves, Gilberto S.
AU - Barbosa, Izabela G.
AU - Cappi, Carolina
AU - Carneiro, Maria Cecília B.
AU - Costa, Daniel L.
AU - Delage, Fernanda Z.
AU - Dreher, Carolina B.
AU - Ferrão, Ygor A.
AU - Ferreira, Gabriela M.
AU - Fontenelle, Leonardo F.
AU - Fragoso, Daniele T.H.
AU - Lima, Monicke O.
AU - Menezes, Gabriela
AU - Miguel, Euripedes C.
AU - Moreira-de-Oliveira, Maria E.
AU - Stumpf, Bárbara Perdigão
AU - Quarantini, Lucas C.
AU - Quarantini-Alvim, Yana
AU - Ramos, Vanessa R.
AU - do Rosário, Maria Conceição
AU - Sampaio, Aline S.
AU - Saraiva, Leonardo C.
AU - Shavitt, Roseli G.
AU - Crowley, James J.
AU - Storch, Eric A.
A2 - Arriaga, Jasmine
N1 - Publisher Copyright: © 2025 Elsevier B.V.
PY - 2025/12/15
Y1 - 2025/12/15
N2 - Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression. Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18–88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated measures of reward responsiveness, OCD, and depression. Network analyses evaluated interrelations among reward responsiveness domains and their links to OCD and depression. Results: Hobbies and social interactions were the most central domains in the reward responsiveness network. Higher OCD severity was uniquely associated with lower responsiveness to social interactions, while higher depression severity was uniquely linked to reduced responsiveness in hobbies and goal-directed behaviors. Conclusions: Reward responsiveness is relevant to both OCD and depression. Interventions that enhance engagement in central domains, such as hobbies and social interactions, may improve outcomes. Future research should explore reward responsiveness in other mental disorders to inform transdiagnostic intervention strategies.
AB - Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression. Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18–88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated measures of reward responsiveness, OCD, and depression. Network analyses evaluated interrelations among reward responsiveness domains and their links to OCD and depression. Results: Hobbies and social interactions were the most central domains in the reward responsiveness network. Higher OCD severity was uniquely associated with lower responsiveness to social interactions, while higher depression severity was uniquely linked to reduced responsiveness in hobbies and goal-directed behaviors. Conclusions: Reward responsiveness is relevant to both OCD and depression. Interventions that enhance engagement in central domains, such as hobbies and social interactions, may improve outcomes. Future research should explore reward responsiveness in other mental disorders to inform transdiagnostic intervention strategies.
UR - https://www.scopus.com/pages/publications/105011404413
U2 - 10.1016/j.jad.2025.119886
DO - 10.1016/j.jad.2025.119886
M3 - Artículo
AN - SCOPUS:105011404413
SN - 0165-0327
VL - 391
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
M1 - 119886
ER -